We are building a portfolio of small molecules modifying protein interactions in oncology, rare diseases and inflammation. 


We modify protein interactions to overcome cancer drug resistance and to offer cure to rare diseases.


Our first program leverages three mechanisms with direct cancer cell killing, no resistance induction and activation of an anti-tumoral immune response.

THERAPPI’S Executive Team

The management team has proven expertise in key areas for a biotech company encompassing identification and validation of novel drug targets, discovery and development of small molecule modifying protein interactions, executive experience in pharma and biotech, and financing experience.

Luc Otten

CEO & founder

He holds an MD, PhD in immunogenetics. (University of Geneva, Switzerland) and brings a rare mix of expertise in medical science, equity finance and management in biotech companies.

Toufic Renno

CSO & founder

He holds a PhD in immunology (McGill University, Canada) and has a long record of discoveries in both academic and pharma industry. He currently leads an academic team at the Lyon Cancer Research Center (Lyon, France).

Isabelle Coste

SVP Biology & founder

She holds a PhD in immunology (University of Lyon, France). She combines biology research experience in academia and industry. She is a tenured researcher (CNRS) within Renno’s academic team at the Lyon Cancer Research Center. team at the

Stéphane Giraud

SVP Drug Dev. & founder

He holds a PhD in molecular and cellular biology (University of Lyon, France). He is experienced in drug discovery in industry and academia. He is the director of Center for Drug Discovery and Development (Lyon, France).

Guido Koch

SVP Medicinal Chemistry

He holds a PhD in chemistry (University of Basel, Switzerland). After 21 years at Novartis (Switzerland), he founded a start-up in complex chemistry. He is the developer of 7 clinical candidate compounds and 1 marketed compound.

Chris Shepherd

SVP Early Clinical Dev.

He holds a PhD in molecular pathology and cancer therapeutics (The Institute of Cancer Research, UK) and brings many years of experience in oncology including academic research and translational development in both pharma and biotech.


The prognosis of patients with advanced cancers remains poor. The RAS-MAPK signaling is hyperactivated in over 40% of human cancers and RAS-MAPK-activating mutations cause rare diseases. The efficacy of current RAS-MAPK inhibitors is undercut by cancer resistance and by their inability to cure these rare diseases.


TheraPPI’s two first programs target a novel protein interaction in the RAS-MAPK pathway discovered by the founder team. Our first program in oncology revolutionizes RAS-MAPK targeting: the new mode of action leverages three mechanisms with direct killing cancer cells, no induction of cancer resistance and activation of an anti-tumoral immune response. 

Our lead program aims to obtain a high rate of clinical responses, to circumvent cancer resistance and to improve the response rate of immunotherapies and thus to offer a better prognosis to patients with advanced cancer.


Protein protein interactions (PPI) are crucial for proper cellular functioning that goes beyond specific functions encoded by any single gene. PPIs form a complex network associated with numerous pathologies such as cancer, metabolic syndrome, infections and neurodegenerative diseases.

These PPI characteristics offer multiple opportunities of future drug development to provide treatments not offered by single gene-targeted therapies.

TheraPPI team leverages biology and chemistry expertise in disease-relevant networks to identify druggable PPIs and develop new treatments for cancer and related diseases.